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Overexpression of choline kinase is a frequent feature in human tumour-derived cell lines and in lung, prostate and colorectal human cancers.
Biochem Biophys Res Commun 2002, 296:580-583. Ramírez de Molina A et al.
Choline kinase alpha expression to predict patient outcome in early stage Non-Small Cell Lung Cancer.
Lancet Oncol 2007, 8:889-97. Ramírez de Molina A et al.
Choline kinase alpha depletion selectively kills tumoural cells.
Curr Cancer Drug Targets 2008, 8(8):709-19. Bañez-Coronel M et al.
Tumor cell metabolism: cancer's Achilles' heel.
Cancer Cell 2008, 13, 472-482. Kroemer, G and Pouyssegur, J.
Involvement of human choline kinase alpha and beta in carcinogenesis: a different role in phospholipid metabolism and biological functions.
Adv Enzyme Regul 2010, 1-12. Gallego-Ortega D, et al.
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